Interactions of Alzheimers BAmyloid with Lipid Membranes

Ka C. Lee, PhD
The University of Chicago (Chicago, IL)
Year Awarded:
1999
Grant Duration:
April 1, 1999 to March 31, 2000
Disease:
Alzheimer's Disease
Award Amount:
$198,570
Grant Reference ID:
A1999057
Award Type:
Standard
Award Region:
US Midwestern

Interactions of Alzheimers BAmyloid with Lipid Membranes

Details

Increasing evidence has suggested that the fibril form of Alzheimer's beta-Amyloid (Ab) is neurotoxic in Alzheimer's disease, and in vitro evidence has suggested that Ab fibrils can be formed at very low peptide concentrations if membrane lipids are present. Dr. Lee's long-range goal is to understand the role of membrane lipids in Ab neurotoxicity. She is screening Ab peptides (Ab-140 and Ab-142) for specific interactions with a variety of individual membrane lipids and with lipid mixtures. After the initial screening, she will use a combination of optical and physical techniques to further characterize the association of Ab peptides with lipids and the effects of the peptides on lipid membranes. She will also characterize fibril formation and obtain high resolution images with atomic force microscopy. Dr. Lee's investigation is one of two studies funded by the Irwin Lee Challenge Grant.
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