Inducible Prion Diseases Caused by Artificial Mutation

Stanley Prusiner, MD, PhD
The Regents of the University of Ca (San Francisco, CA)
Year Awarded:
1997
Grant Duration:
April 1, 1997 to March 31, 1999
Disease:
Alzheimer's Disease
Award Amount:
$200,000
Grant Reference ID:
A1997039
Award Type:
Standard
Award Region:
US Southwestern

Inducible Prion Diseases Caused by Artificial Mutation

Details


Publications

Baskakov, I.V., Legname, G., et al. (2001) Folding of prion protein to its native alpha-helical conformation is under kinetic control. J. Biol. Chem. 276(23):19687-19690.  

Supattapone, S., Bouzamondo, E., et al. (2001) A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice. Mol. Cell. Biol. 21(7): 2608-2616.  

Baskakov, I.V., Aagaard, C., et al. (2000) Self -assembly of recombinant prion protein of 106 residues. Biochemistry 39(10):2792-2804.  

Supattapone, S., Bosque, P., et al. (1999) Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice. Cell. 96(6):869-878.  

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