Free Radicals in BetaAmyloid Neurotoxicity

Ted Dawson, MD, PhD
Johns Hopkins University (Baltimore, MD)
Year Awarded:
1994
Grant Duration:
April 1, 1994 to March 31, 1996
Disease:
Alzheimer's Disease
Award Amount:
$198,622
Grant Reference ID:
A1994118
Award Type:
Standard
Award Region:
US Northeastern

Free Radicals in BetaAmyloid Neurotoxicity

Details


Publications


Aoki, C., Rhee, J., Lubin, M., and Dawson, T.M. (1997) NMDA-R1 Subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines. Brain Res. 750(1-2):25-40.  

Togashi, H., Sasaki, M., Frohma., E., Taira, E., et al. (1997) Neuronal (Type 1) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. Proc. Natl. Acad. Sci. USA. 94(6):2676-2680.  

Steiner, J.P., Connolly, M.A., Valentine, H.L., Hamilton, G.S., et al. (1997) Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nature Medicine. 3(4):421-428.  

Dawson, V.L. and Dawson, T.M. (1996) Free radicals and neuronal cell death. Cell Death and Differentiation. 3(1):71-78.  

[PMID:nd] Dawson, V.L. and Dawson, T.M. (1996) Nitric oxide oxicity in CNS cultures. Methods in Neuroscience. 30:26-43.[link not available] Dawson, V.L., Kizushi, V.M., Huang, P.L., Snyder, S.H., and Dawson, T.M. (1996) Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J. Neurosci. 16(8):2479-2487.  

[Book Chapter] Dawson, T.M. and Dawson, V.L. (1996) NADPH diaphorase staining. In: Methods in Neuroscience: NO Synthase - Methods for Characterization and Functional Analysis of Nitric Oxide Synthase. P.A. Conn and M. Maines, eds. Academice Press, Orlando, FL, 1996, 31:62-67.

Dawson, T.M. and V. L. Dawson. (1996) Generation of isoform-specifc antibodies to nitric oxide synthases. Methods in Enzymology. 268:349-358.  

Dawson, T.M. (1996) Nitric oxide: a brake for bad behavior. Molecular Psychiatry. 1(1):9-10.  

[Book Chapter] Dawson, V.L. and Dawson, T.M. (1996) Nitric oxide actions in the nervous system. In: neurodegenerative diseases. G. Fiskum, ed. Plenum Publishing, New York, N.Y., 1996, pp. 247-262. Adamson, D.C., Dawson, T.M., Zink, M.C., Clements, J.E., and Dawson, V.L. (1996) Neurovirulent simian immunodeficiency virus infection induces neuronal, endothelial and glial apoptosis. Mol. Medicine. 2(4):417-428.  

Steiner, J.P., Dawson, T.M., Fotuhi, M., and Snyder, S.H. (1996) Immunophilin regulation of neurotransmitter release. Mol. Medicine. 2(3):325-333.  

Xia, Y., Dawson, V.L., Dawson, T.M., Snyder, S.H., and Zweier, J.L. (1996) Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells lading to peroxynitrite-mediated cellular Injury. Proc. Natl. Acad. Sci. USA. 93(13):6770-6774.  

[Book Chapter] Dawson, V.L. and Dawson, T.M. (1996) Pathologic roles of nitric oxide in the central nervous system. In: Free Radicals in Brain Physiology and Disorders. L. Packer, M. Hiramatsu and T. Yoshikawa, eds. Academic Press Inc., Orlando, FL, pp. 83-99. Dawson, V.L. and Dawson, T.M. (1996) Nitric oxide neurotoxicity. J. Chemical Neuroanatomy. 10(3-4):179-190.  

[Book Chapter] Dawson, V.L. and Dawson, T.M. (1996) Function of NO in neuronal cell death. In: Methods in Neuoscience: NO Synthase - Characterization and Functional Analysis of Nitric Oxide Synthase. P.A. Conn and M. D. Maines, eds. Academic Press, Orlando, FL, 31:228-240.

Dawson, T.M. (1996) Immunosuppressants, immunophilins and the nervous system. Ann. Neurol. 40(4):559-560.  

[PMID:nd] Resink, A.M., Dawson, V.L., and Dawson, T.M. (1996) Nitric oxide inhibitors: future therapies for CNS disorders. CNS Drugs. 6:351-357.[link not available] [Book Chapter] Aoki, C., Fenstemaker, S., Rhee, J., Song, X.Z., et al. (1996) Nitric oxide-synthesizing neurons in the cerebral cortex: anatomy and functional implications. In: Excitatory Amino Acids and the Cerebral Cortex. F. Conti and T.P. Hicks, eds. MIT Press/Bradford Books, Cambridge, Mass., pp. 155-187. Adamson, D.C., Wildemann, B., Sasaki, M., Glass, J.D., McArthur, J.C., et al. (1996) Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science. 274(5294):1917-1921.  

Yun, H.Y., Dawson, V.L., and Dawson, T.M. (1996) Neurobiology of nitric oxide. Critical Reviews of Neurobiology. 10(3-4):291-316.  

Dawson, T.M. and Dawson, V.L. (1996) Nitric oxide synthase: Role as a transmitter/mediator in the brain and endocrine system. Ann. Rev. Medicine. 47:219-227.  

Dawson, V.L. and Dawson, T.M. (1996) Nitric oxide in neuronal degeneration. Proc. Soc. Exp. Biol. Med. 211(1):33-40.  

[Book Chapter] Dawson, V.L. and Dawson, T.M. (1995) Mechanisms of Nitric Oxide Neurotoxicity In Primary Neuronal Cultures. In: The World Congress on Alternatives and Animal Use in the Life Sciences: Education, Research and Testing. A.M. Goldberg, L.F.M. VanZuphen, and Mary Ann Liebert, eds. Inc Publishers, New York, NY, pp. 133-139. [Book Chapter] Snyder, S.H. and Dawson, T.M. (1995) Nitric oxide and related substances as neural messengers. In: Psychopharmacology: The Fourth Generation of Progess. F.E. Bloom and D.J. Kupfer, eds. Raven Press, pp. 609-618. [Book Chapter] Dawson,V.L. and Dawson, T.M. (1995) Nitric oxide mediates a component of gp l2O neurotoxicity in primary cortical cultures. In: Technical Advances in AlDS Research in the Nervous System. E. 0. Major and J.A. Levy, eds. Plenum Press, pp. 163-173

Dawson, V.L. and Dawson, T.M. (1995) Physiologic and toxicologic actions of nitric oxide in the central nervous system. Advances in Pharmacology. 34:323-342.  

Dawson, V.L. (1995) Nitric oxide: role in neurotoxicity. Clin. Exp. Pharinacol. Physiol. 22:305-308.  

Irikura, K., Huang, P.L., Ma, J., Lee, W.S., et al. (1995) Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc. Natl. Acad. Sci. U.S.A. 92(15):6823-6827.  

Hamada, J., Greenberg, J.H., Croul, S., Dawson, T.M., and Reivich, M. (1995) Effects of central inhibition of nitric oxide synthase on focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 15(5):779-786  

Dawson, V.L., Brahmbhatt, H.P., Mong, J.A., and Dawson, T.M. (1994) Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacol. 33(11):1425-1430.  

[PMID:nd] Dawson, T.M. and Dawson, V.L. (1994) Nitric oxide: actions and pathological roles. Neurosci. Preview Issue, pp. 9-20.[link not available] Lynch, D.R. and Dawson, T.M. (1994) Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7(6):510-516.  

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