Mitochondrial defects in familial Alzheimer's disease

Eric Schon, PhD
Columbia University (New York, NY)
Year Awarded:
2008
Grant Duration:
April 1, 2008 to March 31, 2010
Disease:
Alzheimer's Disease
Award Amount:
$150,000
Grant Reference ID:
A2008111
Award Type:
Pilot
Award Region:
US Northeastern
Eric Schon, PhD

ER-Mitochondrial interactions in familial Alzheimer's disease

Summary

ER-Mitochondrial interactions in familial Alzheimer's disease

Details


We have discovered that presenilin-1, a protein that, when mutated, causes familial (i.e. inherited) Alzheimer disease, is located in a specialized compartment of the cell, called endoplasmic reticulum-mitochondria-associated membranes (ER-MAM). This novel finding suggests a new mechanism by which the disease arises. We propose a number of experiments aimed at understanding the role of ER-MAM in the pathogenesis of Alzheimer disease.

Publications

Area*Gomez E, de Groof AJC, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA (2009). Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am. J. Pathol. 175, 1810-1816.  

Schon EA, Area Gomez, E (2010). Is Alzheimer's disease a disorder of mitochindria-associated membranes? J. Alz. Dis. , accepted for publication, pending minor revisions.  

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