ER-Mitochondrial interactions in familial Alzheimer's disease
We have discovered that presenilin-1, a protein that, when mutated, causes familial (i.e. inherited) Alzheimer disease, is located in a specialized compartment of the cell, called endoplasmic reticulum-mitochondria-associated membranes (ER-MAM). This novel finding suggests a new mechanism by which the disease arises. We propose a number of experiments aimed at understanding the role of ER-MAM in the pathogenesis of Alzheimer disease.
Schon EA, Area Gomez, E (2010). Is Alzheimer's disease a disorder of mitochindria-associated membranes? J. Alz. Dis. , accepted for publication, pending minor revisions.
First published on: June 10, 2008
Last modified on: August 20, 2010