Dynamic OGlycosylation and Alzheimer's Disease

Gerald Hart, PhD
Johns Hopkins University School of (Baltimore, MD)
Year Awarded:
1998
Grant Duration:
April 1, 1998 to March 31, 2000
Disease:
Alzheimer's Disease
Award Amount:
$200,000
Grant Reference ID:
A1998029
Award Type:
Standard
Award Region:
US Northeastern

Dynamic OGlycosylation and Alzheimer's Disease

Details


Publications

Kreppel LK, Hart GW. Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats. J Biol Chem. 1999 Nov 5;274(45):32015-22. PubMed  

. Cole RN, Hart GW. Cytosolic O-glycosylation is abundant in nerve terminals. J Neurochem. 2001 Dec;79(5):1080-9. PubMed  

. Cole RN, Hart GW. Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions. J Neurochem. 1999 Jul;73(1):418-28. PubMed  

Hart GW, Cole RN, Kreppel, LK, Arnold CS, Comer FI, Iyer S, Cheng X, Carroll J, and Parker GJ. (1988) Glycosylation - A Major Challenge in Mass Spectrometry and Proteomics, in Proceedings of the 4th International Symposium on Mass Spectroometry in the Health &Life Sciences, eds. Burlingame, Carr, Baldwin. Human Press. Kreppel LK, Hart GW (1999). Functional Significance of O-GlcNAc Glycoproteins in the Cytoplasm and Nucleus, ed. Fukada, Hindsgaul. in Molecular and Cellular Glycobiology: Frontiers in Molecular Biology; Oxford Univ. Press. Oxford, UK. Acosta-Serrano A, Cole RN, Englund PT. Killing of Trypanosoma brucei by concanavalin A: structural basis of resistance in glycosylation mutants. J Mol Biol. 2000 Dec 8;304(4):633-44. PubMed  

. Cole RN, Hart GW. Cytosolic O-glycosylation is abundant in nerve terminals. J Neurochem. 2001 Dec;79(5):1080-9. PubMed  

. Cheng X, Cole RN, Zaia J, Hart GW. Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. Biochemistry. 2000 Sep 26;39(38):11609-20. PubMed  

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