Domain Analysis of PN2/APP751Interactions with LRP

Mary Knauer, PhD
Regents of the University of the University of California - Irvine (Irvine, CA)
Year Awarded:
1999
Grant Duration:
April 1, 1999 to March 31, 2000
Disease:
Alzheimer's Disease
Award Amount:
$190,864
Grant Reference ID:
A1999044
Award Type:
Standard
Award Region:
US Southwestern

Domain Analysis of PN2/APP751Interactions with LRP

Details

Dr. Knauer is studying the interaction of two forms of the amyloid precursor protein (also known as Protease nexin 2 or PN2) with the low-density lipoprotein receptor related protein (LRP). By binding to LRP, PN2 can be reintroduced to the interior of the cell, and there is evidence to suggest that this may be important in Alzheimer's disease. To understand how these proteins interact, the site of binding in the PN2 molecules will be mapped as well as the corresponding binding site in the LRP molecule. This information may be useful for developing molecular mimics, or agonists, that could prevent LRP-PN2 interaction, re-internalization, and, it is hoped, the formation of amyloid beta protein.
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