Studying Proteins in Blood to Detect Alzheimer's Disease at an Early Stage

Veer Bala Gupta, PhD
Edith Cowan University (Perth, Australia)

Mentors

Ralph Martins, PhD
Edith Cowan University (Perth, Australia)
Year Awarded:
2015
Grant Duration:
July 1, 2015 to December 31, 2017
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2015641F
Award Type:
Postdoctoral Fellowship
Award Region:
International
Veer Bala Gupta, PhD

Developing a Blood-Based Biomarker Panel for Alzheimer's Disease

Summary

While much progress has been made over understanding Alzheimer’s disease (AD) pathology and using neuroprotective strategies and some effort spent on brain imaging changes in AD we still lag far behind in developing reliable, sensitive, non-invasive and cost-effective diagnostic biomarkers which can be used before and during the course of a therapeutic intervention. There is substantial evidence to indicate that early stages of Alzheimer’s Disease coincide with specific protein changes in peripheral body fluids particularly blood and these changes subsequently also reflect aggravation of AD pathology during its time-course. Age related protein changes pose a major hurdle to identify and differentiate the specific AD biomarkers due to high prevalence of the disease in aged populations. We propose that investigating familial form of AD will be an innovative approach to identify and develop reliable blood-based biomarkers for this disease.

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