Copper/cholesterol interaction in Alzheimer's Disease

Ashley Bush, MD, PhD
Mental Health Researrch Institute of Victoria (Parkville, Victoria, Australia)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to March 31, 2007
Disease:
Alzheimer's Disease
Award Amount:
$300,000
Grant Reference ID:
A2005091
Award Type:
Standard
Award Region:
International

Copper/cholesterol interaction in Alzheimer's Disease

Details


In Alzheimer's disease a normal protein called beta-amyloid (Aβ) has been found to accumulate abnormally in the brain. AD has also been associated with abnormalities in cholesterol metabolism. Both links, however, are complex and the results of their specific effects have not yet been pin-pointed. Dr. Bush's team has discovered Aβ to be a copper binding protein. Copper (like cholesterol) is a normally abundant part of brain chemistry, but in AD Aβ abnormally utilizes copper's chemical energy to convert cholesterol into hydrogen peroxide. This is a damaging reaction that may be the cause of the toxicity of Aβ. Through a five part research analysis, Dr. Bush's studies will help illuminate the complex biochemistry of Aβ in its reactions with copper and cholesterol in the brain.

Publications

Adlard, P. and Bush, A.I. (2006) Metals and Alzheimer's disease. Journal of Alzheimer's disease. 10(2-3):145-163.  

Frederickson, C.J., Koh, J.Y., Bush, A.I. (2005) The neurobiology of zinc in health and disease. Nat Rev Neurosci. Jun;6(6):449-62  

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