Cognitive Performance in Adolescence, APOE and AD

Thomas Fritsch, PhD
Case Western Reserve University (Cleveland, OH)
Year Awarded:
Grant Duration:
April 1, 2002 to March 31, 2003
Alzheimer's Disease
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Midwestern

Cognitive Performance in Adolescence, APOE and AD


Researchers have suggested that there is a relationship between cognitive performance early in life and the development of Alzheimer's disease (AD) later in life, but few studies have directly tested this relationship. Also, there have been no investigations to examine whether the genetic factor, apolipoprotein E4 (apoE4), modifies the possible relationship. There are two main goals of this investigation by Dr. Fritsch. First, he will use information from archived school records and yearbooks to study relationships between cognitive performance, grades and participation in school activities in adolescence and the development of AD in adulthood. Second, he will collect genetic material in order to study the possible modifying role of apoE. These studies should lead to understanding the early roots of AD and help evaluate whether AD is a developmental process or a long-term chronic disorder.


Fritsch, T., Smyth, K. A., McClendon, M. J., Ogrocki, P. K., Santillan, C., Larsen, J. D., & Strauss, M. E. (2005). Associations between dementia/mild cognitive impairment and cognitive performance and activity levels in youth. Journal of the American Geriatrics Society, 53, 1191-1196.  

Fritsch, T., Ziol, E., Emancipator, K., Smyth, K., McClendon, M., Ogrocki, P., Santillan, C., Lemere, W., Hustak, L. (2003). Relationships between cognitive performance in adolescence and memory and cognitive function in adulthood. Gerontologist, 43, 37. [PMID: nd][link not available]
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