Cholinergic Vulnerability in Amyloid-Positive Elderly
After over one year of preparatory work, the team has now begun the single-blind phase of testing to ensure that they have the correct dose of scopolamine. They have completed five subjects and have four more currently enrolled in the study. Dr. Sperling’s team has already detected evidence of subtle behavioral and functional imaging changes with low dose scopolamine.
Vannini P, O'Brien J, O'Keefe K, Pihlajamaki MM, LaViolette P, Sperling RA. (2011) What goes down must come up: Role of the posteromedial cortices in encoding and retrieval. Cerebral Cortex, Jan; 1:22-34. Epub 2010 Apr 2.
Putcha D, O'Keefe K, LaViolette P, O'Brien J, Greve D, Locascio J, Atri A, Rentz DM, Sperling RA. (2011) Reliability of fMRI associative encoding memory paradigm in non-demented elderly adults. Human Brain Mapping, Dec; 32(12):2027-44. doi: 10.1002/hbm.21166. Epub 2011 Jan 21.
Becker JA, Hedden T, Carmasin J, Maye J, Rentz D, Putcha D, Fischl B, Greve D, Marshall GA, Salloway S, Marks D, Buckner RL, Sperling RA, Johnson KA. (2011) Amyloid-beta associated cortical thinning in clinically normal elderly. Annals of Neurology Jun; 69(6):1032-42. doi: 10.1002/ana.22333. Epub 2011 Mar 17.
Vannini P, Hedden T, Becker JA, Sullivan C, Putcha D, Rentz D, Johnson KA, Sperling RA. (2011) Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiology of Aging, Jul; 33(7):1237-52. Epub 2011 Feb 18.
Atri A, O'Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O'Keefe KM, LaViolette PS, Rentz DM, Locascio JJ, Sperling RA. (2011) Test-retest reliability of memory task fMRI in Alzheimer's disease clinical trials. Archives of Neurology, May; 68:5:599-606.
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan A, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, SternY, Yaffe K, Carillo MC, Thies W, Morrison-Bogorad M, Wagster M, Phelps CH. (2011) Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer Association Workgroup. Alzheimer's & Dementia, May; 7(3):280-92. Epub 2011 Apr 21.
Rentz DM, Amariglio RE, Becker JA, Frey M, Olson LE, Frishe K, Carmasin J, Maye JE, Johnson KA, Sperling RA. (2011) Face-Name Associative Memory Performance is Related to Amyloid Burden in Normal Elderly. Neuropsychologia, Jul; 49(9):2776-83. Epub 2011 Jun 12.
Sperling R, Jack CR, Aisen P. (2011) Testing the right target, the right drug, at the right stage: Secondary prevention trials in Alzheimer's disease. Science Translational Medicine, Nov 30;3(111):111cm33.
Amariglio R, Frishe K, Olson L, Wadsworth L, Lorius N, Sperling R, Rentz, D. (2012) Validation of the Face Name Memory Exam in cognitively normal older individuals. Journal of Clinical and Experimental Neuropsychology, Jul;34(6):580-7. Epub 2012 Mar 9.
Vannini P, Hedden T, Huijbers W, Ward A, Johnson KA, Sperling RA. (2013) The Ups and Downs of the Posteromedial Cortex: Age- and Amyloid-Related Functional Alterations of the Encoding/Retrieval Flip in Cognitively Normal Older Adults. Cerebral Cortex, Jun;23(6):1317-28. doi: 10.1093/cercor/bhs108. Epub 2012 May 14.
First published on: April 2, 2010
Last modified on: August 8, 2013