Biology of Novel Amyloid Component Precursor

Tsunao Saitoh, PhD
The Regents of the University of CA (La Jolla, CA)
Year Awarded:
1994
Grant Duration:
April 1, 1994 to March 31, 1996
Disease:
Alzheimer's Disease
Award Amount:
$200,000
Grant Reference ID:
A1994024
Award Type:
Standard
Award Region:
US Southwestern

Biology of Novel Amyloid Component Precursor

Details

Publications

Xia, Y., De Silva, H.A.R., Rosi, B.L., Yamaoka, L.H., et al. (1996) Genetic studies in Alzheimer's disease with an NACP/a-synuclein polymorphism. Ann. Neurol. 40:207-215.  

Masliah, E., Iwai, A., Mallory, M., Ueda, K., et al. (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148(1):201-210.  

Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., et al. (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 14:467-475.  

Iwai, A., Yoshimoto, M., Masliah, E., and Saitoh, T. (1995) Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochem. 34:10139-10145.  

Yoshimoto, M., Iwai, A., Kang, D., Otero, D.A., et al. (1995) NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation. Proc Natl Acad Sci USA. 92(20):9141-9145.  

Chen, X., De Silva, H.A.R., Pettenati, M.J., Rao, P.N., et al. (1995) The human NACP/a-synuclein gene: chromosome assignment to 4q21.3-q22 and taq1 RFLP analysis. Genomics. 26:425-427.  

Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., et al. (1995) The precursor protein of non-A-beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 14:467-75.  

Ueda, K., Saitoh, T., and Mori, H. (1994) Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A-beta component of Alzheimer's disease amyloid. Biochem. Biophys. Res. Comm. 205:1366-1372.  

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