The APP/FE65 complex in regulating neurite outgrowth

Annat Ikin, PhD
Thomas Jefferson University (Philadelphia, PA)
Year Awarded:
2004
Grant Duration:
April 1, 2004 to March 31, 2006
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2004255
Award Type:
Standard
Award Region:
US Northeastern

The APP/FE65 complex in regulating neurite outgrowth

Details


Alzheimer's disease (AD) is believed to be caused by the excess accumulation of amyloid beta (Aß) in the brain. It is well known that Aß is derived through the processing of a larger molecule, the amyloid precursor protein (APP). Determining the function of APP will further an understanding of the pathological events leading to AD and should help to identify therapeutic targets that do not disrupt normal brain functions. Dr. Ikin believes that proteins that bind to APP could potentially modify its function. One such protein is the cytosolic adapter FE65. Dr. Ikin has already shown that APP and FE65 both localize in a region of neuronal growth cones along with mena, which regulates membrane motility and is required for normal neural development. This suggests that a constellation of factors involving APP and FE65 may play a role in growth cone motility. In this project, Dr. Ikin is testing the hypothesis that APP, FE65, and one or more additional proteins form a complex involved in the regulation of growth cone movement and neurite outgrowth. The function of this complex may have direct implications for AD, since the loss of neural connections and neuronal sprouting are prominent features of Alzheimer's disease pathology.

Publications

Ikin, A.F., Sabo, S.L., Lanier, L.M., Buxbaum, J.D. (2007) A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching. Mol Cell Neurosci. 35(1):57-63.  

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