Antioxidant defense in Alzheimer's brain in vivo

In-Young Choi, PhD
University of Kansas Medical Center (Kansas City, KS)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to March 31, 2007
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2005237
Award Type:
Standard
Award Region:
US Midwestern

Antioxidant defense in Alzheimer's brain in vivo

Details

Oxidative stress plays an important role in age-related pathophysiology such as Alzheimer's disease. However, the effects of oxidative stress in the living brain with Alzheimer's disease have not been clearly described. The objective of Dr. Choi's project is to measure a molecule in the brain called Glutathione (GSH), which reflects the antioxidant defense system, and its regional variation in the living human brain to explain the role of oxidative stress in Alzheimer's disease. The identification of an important biomarker in the living brain tissue will be particularly valuable for evaluating the effects of antioxidant therapy in patients with Alzheimer's disease in the future.
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