Alzheimer's Disease, Before Plaques And Tangles
In this application, we propose to study the postmortem brain of individuals between 30 and 50 years of age and to identify those brains with the very early pathologic changes or lesions of Alzheimer’s disease. Then, we will study whether these lesions are associated with other abnormalities and whether they cause degeneration and death of brain nerve cells. Information obtained from this study could eventually help the development of new diagnostic tests and treatments for Alzheimer’s disease.
Tward D, Brown T, Kageyama Y, Patel J, Hou Z, Mori S, Albert M, Troncoso J, Miller M. Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease. Frontiers in Neuroscience. 2020;14.
Bell WR, An Y, Kageyama Y, English C, Rudow GL, Pletnikova O, Thambisetty M, O'Brien R, Moghekar AR, Albert MS, Rabins PV, Resnick SM, Troncoso JC. Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease. Alzheimers Dement. 2018 Nov 19. pii: S1552-5260(18)33483-6. doi: 10.1016/j.jalz.2018.07.215. [Epub ahead of print] PubMed PMID: 30465754.
Kageyama Y, Saito A, Pletnikova O, Rudow GL, Irie Y, An Y, Murakami K, Irie K, Resnick SM, Fowler DR, Martin LJ, Troncoso JC. Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep. 2018 Nov 15;8(1):16895. doi: 10.1038/s41598-018-35004-3. PubMed PMID: 30442978.
First published on: July 27, 2015
Last modified on: March 18, 2020