Alzheimer's Disease, Before Plaques And Tangles

Juan Troncoso, MD
Johns Hopkins University (Baltimore, MD)

Co-Principal Investigators

Lee J. Martin, PhD
Johns Hopkins University (Baltimore, MD)
Year Awarded:
Grant Duration:
July 1, 2015 to June 30, 2017
Alzheimer's Disease
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Northeastern

This grant is made possible by a bequest from the Howlett Revocable Trust. 

Alzheimer's Disease, Before Plaques And Tangles


In this application, we propose to study the postmortem brain of individuals between 30 and 50 years of age and to identify those brains with the very early pathologic changes or lesions of Alzheimer’s disease. Then, we will study whether these lesions are associated with other abnormalities and whether they cause degeneration and death of brain nerve cells.  Information obtained from this study could eventually help the development of new diagnostic tests and treatments for Alzheimer’s disease.


Tward D, Brown T, Kageyama Y, Patel J, Hou Z, Mori S, Albert M, Troncoso J, Miller M. Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease. Frontiers in Neuroscience. 2020;14. PubMed Icon Google Scholar Icon

Bell WR, An Y, Kageyama Y, English C, Rudow GL, Pletnikova O, Thambisetty M, O'Brien R, Moghekar AR, Albert MS, Rabins PV, Resnick SM, Troncoso JC. Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease. Alzheimers Dement. 2018 Nov 19. pii: S1552-5260(18)33483-6. doi: 10.1016/j.jalz.2018.07.215. [Epub ahead of print] PubMed PMID: 30465754. PubMed Icon Google Scholar Icon

Kageyama Y, Saito A, Pletnikova O, Rudow GL, Irie Y, An Y, Murakami K, Irie K, Resnick SM, Fowler DR, Martin LJ, Troncoso JC. Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep. 2018 Nov 15;8(1):16895. doi: 10.1038/s41598-018-35004-3. PubMed PMID: 30442978. PubMed Icon Google Scholar Icon

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