Brain Changes in Alzheimer's Disease, Role of A Blood Pressure System

Peter Abadir, MD
Johns Hopkins University (Baltimore, MD)
Year Awarded:
2019
Grant Duration:
July 1, 2019 to June 30, 2022
Disease:
Alzheimer's Disease
Award Amount:
$300,000
Grant Reference ID:
A2019634S
Award Type:
Standard
Award Region:
US Northeastern
Peter Abadir, MD

Characterizing Brain Angiotensin System

Summary

This study is designed to evaluate specific factors that may play a role in development and progression of Alzheimer’s Dementia. Angiotensin receptors 1, 2 and 4 (AT1R, AT2R and AT4R) are found on brain cells and play an important function in brain vital functions. This study will examine changes in these receptors in brain cells in patients with Alzheimer’s dementia. We will also study the impact of a class of drugs that target these receptors and commonly used to treat high blood pressure. 

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