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National Glaucoma Research
Completed Award

Dr. Paul Kaufman

Paul Kaufman, M.D.

Board of Regents of the University of Wisconsin System
Madison, WI

Title: Vitamin D Effects On Anterior Segment Physiology In Monkeys
Non-Technical Title: Vitamin D, A Potential Glaucoma Therapy?

Duration: April 1, 2009 - March 31, 2011
Award Type: Standard
Award Amount: $100,000

Summary:

Is vitamin D a potential glaucoma therapy? Can it lower intraocular pressure after topical application? What are the target tissues in the eye and what is the mechanism for the intraocular pressure lowering effect?

Details:

The number of health benefits attributed to vitamin D continues to increase. We would like to know if it has the potential to lower the internal pressure of the eye (or “intraocular pressure”) and be further developed as a glaucoma therapy. Since it is a molecule produced naturally in the human body, the number of side effects are likely to be minimal.

Progress Updates:

Dr. Paul Kaufman and colleagues tested whether topical application of vitamin D (vitD) could lower intraocular pressure (IOP). Monkeys with normal IOP were treated topically twice daily with a form of vitD to one eye and with a control on the opposite eye. IOP was measured on several different days, along with pupil diameter, blood calcium levels, blood pressure, and heart rate. Fluid (aqueous humor) flow in the eye was measured in a small set of animals. Fluid outflow facility (the ease at which the aqueous leaves the eye) was measured after injection of vitD or after a topical treatment was administered twice daily and followed by a supplementary injection or after topical treatment only. IOP decreased dose‐dependently following topical treatment, with a maximum reduction of 20‐30% lasting one to four hours. IOP reduction often occurred in both eyes. No further reduction in IOP was achieved with prolonged treatment. No inflammation was detectable in the eyes at any time‐point. Prolonged treatment (12 days) may produce systemic effects.

Dr. Kaufman determined that VitD lowers IOP in monkeys, but the mechanism of action is not apparent using a number of experimental approaches. However, topical application of VitD has potential for development as an anti‐glaucoma drug to be further pursued in future studies.