Text Size Normal Text Sizing Button Medium Text Sizing Button Large Text Sizing Button Text Contrast Normal Contrast Button Reverse Contrast Button Switch to Spanish Language Press Room Contact Us Sitemap Sign In Register
Link to Homepage About BrightFocus
BrightFocus
Donate Now Get Involved  
Alzheimer's Disease Research Macular Degeneration Research National Glaucoma Research


Sign up for Email Notifications
If you would like to be notified when funding or meeting opportunities are announced please click on the link below.

Sign up for new announcements.

Please add ResearchGrants@BrightFocus.org to your institution’s white list to insure that the notification is not blocked by your organization’s SPAM filters.

This email list is not sold or distributed, and serves only as an annual reminder of the availability of research support through the BrightFocus Foundation (www.brightfocus.org). Please follow instructions on the notification emails for removal requests.

 
 
BrightFocus Research Grants Funding
Grant Funding for Alzheimer's Research
Grant Funding for Macular Degeneration Research
Grant Funding for Glaucoma Research
 

 

Macular Degeneration Research
Current Award

Photo Pending

Alfred Lewin, Ph.D.

University of Florida
Gainesville, FL, United States

Title: Treatment of Retinal Degeneration in a Mouse Model for Dry AMD
Non-Technical Title: Treatment of Retinal Degeneration in a Mouse Model for Dry Form of AMD

Acknowledgements: Elizabeth Anderson Award for Macular Degeneration Research awarded to original Principal Investigator, Dr. Haoyu Mao.
Duration: July 1, 2012 - June 30, 2015
Award Type: Standard
Award Amount: $100,000

Summary:

Currently, there is no effective treatment for the early form of AMD, called dry AMD. Therefore, Dr. Lewin and colleagues aim to develop a new treatment for dry AMD by testing whether specific drugs can protect the retinal pigment epithelium (RPE) from succumbing to oxidative stress.

Notes:

This grant was originally awarded to Haoyu Mao, Ph.D., and transferred to Alfred Lewin, Ph.D., at Dr. Mao’s request when she left the University of Florida for another position in September 2013.

Details:

Currently there is no treatment for dry AMD. To find a treatment, Dr. Lewin and colleagues are testing systemic delivery of three different drugs in mice engineered to have their RPE cells missing a gene (SOD2) that's involved in oxidative stress. Oxidative stress has been shown to play an important role in causing AMD. Results of these studies may lead to new therapies.

Lewin's use of systemically deliverable therapeutic reagents is unique, and one of the compounds the team is testing has already been through Phase III trials for another disease involving nerve cells, namely Amyotrophic Lateral Sclerosis (ALS). The drug Lewin is testing is orally available and approved for human use.

If the research aims are successful, the team will take several steps to bring this information, and a potential dry AMD treatment, to patients. The first step would be to re-test the successful reagents in different AMD mice that are not directly related to RPE oxidative stress. Since preclinical information and human safety profiles are characterized for these compounds, this may accelerate bringing the drugs to clinical trial. In addition, if either class of compound shows promise, Lewin's team would initiate a collaboration with a medicinal chemist to modify the compounds for local delivery to the eye. Fortunately, there is a strong program in Medicinal Chemistry in the College of Pharmacy at the University of Florida, and these scientists already have a collaboration with Dr. Hendrik Luesch in that department.