Alzheimer's Disease Research
Catherine Clelland, Ph.D.
New York, NY
Title: The Role of miR-138 in Alzheimer's Disease Dendritic Spine Pathology
Non-Technical Title: Exploring a novel abnormal regulatory pathway in Alzheimer's disease brain cell connections
Duration: April 1, 2010 - September 30, 2012
Award Type: Pilot
Award Amount: $150,000
We will test if dysregulation of the miR-138 controlled pathway contributes to dendritic spine pathology in a murine tauopathy model. We believe this project is highly innovative because if successful, this study will be one of the first to directly link the dysregulation of a miRNA regulated pathway to the in vivo dendritic spine pathology seen in a mouse model of human tauopathy.
We are going to investigate the role of an important class of regulatory proteins in Alzheimer's disease. The success of this project may be beneficial to the public in the form of new treatment developments.