Macular Degeneration Research
Wilmer Eye Institute
Title: Advanced Glycation Endproduct Mediated Cholesterol Deposition in Bruch's Membrane
Duration: April 1, 2005 - March 31, 2007
Award Type: Standard
Award Amount: $99,545
When looking at AMD eyes under the microscope, the most distinguishing change is basal deposits, or accumulations of material within Bruch’s membrane, a specialized scaffold upon which the retinal pigment epithelium (RPE) attaches. Prior to basal deposit formation, cholesterol (fat) is deposited into Bruch’s membrane. Dr. Handa believes that understanding how cholesterol gets deposited into Bruch’s membrane will help researchers to design targeted new treatments that prevent the onset of AMD or slow the inevitable progression from early to late disease.
Wu T, Tian J, Cutler RG, Telljohann RS, Bernlohr DA, Mattson MP, Handa JT. Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells. Lab Invest. 2010 Jun;90(6):906-14. Epub 2009 May 11.