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BrightFocus Research Grants Funding
Grant Funding for Alzheimer's Research
Grant Funding for Macular Degeneration Research
Grant Funding for Glaucoma Research


2013 BrightFocus Research Awards

BrightFocus 2014
Research Grant Awards Offered

Alzheimer's Disease


Macular Degeneration

Alzheimer's Disease

Inhibiting Tryptophan Metabolism in Alzheimer’s Disease
Katrin Andreasson, MD
Stanford University

Vascular Function and Cognition in Type 2 Diabetes
Michal Schnaider Beeri, PhD
Sheba Medical Center

Purification and Characterization of Amyloid-beta Oligomers from Human Brain
David Brody, MD, PhD
Washington University School of Medicine

Role of EHD Proteins in Alzheimer's Disease Pathogenesis
Virginie Buggia-Prevot, PhD
University of Chicago

Genomic Editing to Elucidate CD33 Function
Steven Estus, PhD
University of Kentucky

Differential Uptake of Tau Fibrils into Neurons and Glia
Kristen Funk, PhD
Washington University School of Medicine

Mouse Model for Sporadic Tauopathies
Jing Guo, PhD
University of Pennsylvania School of Medicine

Nrf2 Regulates Tau Clearance: An Alzheimer’s Disease Treatment Strategy
Gail Johnson, PhD
University of Rochester Medical Center

Implication of a Mitochondrial Protein, ECSIT, in the Oxidative Stress Leading to Alzheimer’s Disease
Alice Lepelley, PhD
Columbia University Medical Center

Brain Neuronal Types Accumulating PIB-Binding Abeta in Alzheimer’s Disease
Harry LeVine, III, PhD
University of Kentucky

Targeting Intracellular versus Extracellular Tau with Recombinant Antibodies
Yona Levites, PhD
University of Florida

Stress Response Networks in Organismal Proteostasis
Jian Li, PhD
Northwestern University

A New Method to Reduce Alzheimer Phenotypes by Increasing Glutamate Transporter Expression
Chien-liang Lin, PhD
The Ohio State University Research Foundation

Validating ADAM10 as a Therapeutic Target for Dementia
Elena Marcello, PhD
University of Milan

Bif-1 Therapy for Cognitive Impairment and Neuropathology in Alzheimer’s Disease
Richard Morrison, PhD
University of Washington School of Medicine

Alzheimer’s Disease with Cerebrovascular Comorbidity: A Novel Therapy
M. Paul Murphy, MA, PhD
University of Kentucky

Metabolomic/Lipidomic Analysis of ApoE Isoform Effects
Tal Nuriel, PhD
Columbia University Medical Center

Tau, Aβ and Network Degeneration in Alzheimer’s Disease
Rik Ossenkoppele, PhD
Alzheimer Center of the VU University medical center

Novel Cerebrospinal Fluid Biomarkers in Familial Alzheimer Disease
Richard Perrin, MD, PhD
Washington University School of Medicine

Transcriptional Mechanisms of Memory Loss in Alzheimer´s Disease
Carlos Saura, PhD
Universitat Autonoma de Barcelona

Synaptic Regulation of Aβ Metabolism and Secreted Markers
Mitsuru Shinohara, PhD
Mayo Clinic Jacksonville

Using Mouse Models to Study the Role of Ubiquilin-1 in Alzheimer’s Disease
Hongmin Wang, PhD
University of South Dakota

Protein Homeostasis in Mouse Models of Alzheimer’s Pathology
Guilian Xu, PhD
University of Florida


Macular Degeneration

Inflammatory Cells In Choroid During Age-Related Macular Degeneration in Relationship to Retinal Pigmented Epithelium (RPE) Atrophy and Vascular Attenuation
Imran Bhutto, MD, PhD
Wilmer Eye Institute

Mechanisms of Signaling in the Fovea
Michael Do, PhD
Children's Hospital Boston, Harvard Medical School

Engineering Dental Pulp Cells to Create Retinal Pigmented Epithelial Cells on a Bio-Mimetic Silk Membrane
Behzad Gerami-Naini, PhD
Tufts University

Autophagy, a Critical Pathway in the Pathophysiology of Age-Related Macular Degeneration
Nady Golestaneh, PhD
Georgetown University

Novel Genetic Model of Choroidal Neovascular Age-Related Macular Degeneration
Neena Haider, PhD
The Schepens Eye Research Institute

Mechanisms By Which Cxcr5 Regulates Pathogenesis of Macular Degeneration
Hu Huang, PhD
Wilmer Eye Institute

HtrA1 Is Required for Retinal Pigment Epithelia Survival During Endoplasmic Reticulum Stress
Andrius Kazlauskas, PhD
The Schepens Eye Research Institute

Inflammasome Regulation in Age-Related Macular Degeneration
Alexander Marneros, MD, PhD
Massachusetts General Hospital

Simultaneous Structural and Functional Imaging of the Retinal Pigment Epithelium
Omid Masihzadeh, PhD
University of Colorado Eye Center

Macrophages Drive Neovascular Remodeling in Neovascular Age-Related Macular Degeneration
Priyatham Mettu, MD
Duke University Eye Center

Exogenous Peptidase for Amyloid-beta Degradation
David Pepperberg, PhD
University of Illinois at Chicago

Understanding How Dysregulation of Autophagy/Phagocytosis Activates the Immune System in Retinal Pigmented Epithelium Cells, Leading to Age-Related Macular Degeneration
Debasish Sinha, PhD
Johns Hopkins University

Control of Innate Inflammatory Responses in the Retina
Debra Thompson, PhD
Regents of the University of Michigan

Role of Zinc and HAP in Inducing Sub-Retinal Pigmented Epithelium Deposits and Age-Related Macular Degeneration
Richard Thompson, PhD
University of Maryland School of Medicine

Establishing the Foveal Retina During Embryonic Development
Sara Venters, PhD
The Regents of the University of California, San Francisco

Interindividual Variation in Retinal Pigmented Epithelium Energy Metabolism and Regulation of the Process
Douglas Vollrath, MD, PhD
Stanford University



A Mouse Glaucoma Model and Cell Therapy for Glaucoma
Yiqin Du, MD, PhD
University of Pittsburgh

Discovery of Pigment Dispersion Syndrome and Pigmentary Glaucoma Genes by Exome Sequencing
Baojian Fan, MD, PhD
Massachusetts Eye and Ear Infirmary

Hypoxic Conditioning for Protection in DBA/2J Glaucoma Model
Jeff Gidday, PhD
Washington University School of Medicine

Identification and In Vivo Validation of Novel Genes for Developmental Glaucoma
Douglas Gould, PhD
The Regents of the University of California, San Francisco

Optic Nerve Structure and Gene-Environment Association
David Mackey, MD
Lions Eye Institute

Crosstalk of TGF-Beta and TLR4 Pathways in the Trabecular Meshwork
Colleen McDowell, PhD
University of North Texas Health Science Center

Neuroinflammation: The Role of Lymphocytes In Glaucoma
Stuart McKinnon, MD, PhD
Duke University Eye Center

An Implantable System for Intraocular Pressure Measurement and Control
Chris Passaglia, PhD
University of South Florida

Use of Small Molecules to Control Extracellular Matrix Homeostasis
Donna Peters, PhD
Board of Regents of the University of Wisconsin System

An Individualized Model to Predict and Monitor Glaucoma Progression Using Structural and Functional Data
Lyne Racette, PhD
Indiana University School of Medicine

Oxidative Stress and SUMOylation in Pathobiology of Trabecular Meshwork
Dhirendra Singh, PhD
University of Nebraska Medical Center

Altered Versican Fibrillar Interactions in the Outflow Pathway
Janice Vranka, PhD
Oregon Health and Science University

Glia-Mediated Blood Flow Autoregulation in Glaucoma
Lin Wang, MD, PhD
Legacy Health System

Developing Dual Leucine Zipper Kinase Inhibitors for Glaucoma
Derek Welsbie, MD, PhD
Johns Hopkins University


Last Review: 07/01/14