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Could clonidine or other antihypertensive drugs possibly cause the onset of Alzheimer’s disease?

The sedative effects of clonidine and some other antihypertensive drugs can lead to deficits in attention and mild cognition impairments, particularly in elderly individuals, but there does not appear to be any evidence in the medical literature suggesting that clonidine or other antihypertensive agents actually cause dementia. On the contrary, most studies indicate that the use of antihypertensive agents to lower blood pressure is associated with a lowered risk of developing cerebrovascular disease, such as stroke, vascular dementia or Alzheimer's disease.

Posted 15 Apr 2009

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