Wet Macular Degeneration Treatment May Increase Intraocular Pressure
October 26, 2009
Adapted from the American Academy of Ophthalmology
Some patients with age-related macular degeneration (AMD) develop elevated pressure within the eye following treatment with anti-VEGF medications Lucentis and/or Avastin, reports a Yale University School of Medicine study led by Ron A. Adelman, M.D., MPH. Both of these anti-VEGFs control the abnormal growth of blood vessels in the eye's retina and are very effective against wet AMD, which can result in vision loss or blindness if untreated. But high eye pressure is a key factor in glaucoma, also a potentially blinding disease. Of 116 Yale study patients treated for wet AMD with either or both medications from 2006 to 2008, 3.45 percent (four patients) developed a significant and persistent rise in eye pressure.
"To our knowledge, ours is the first study to document persistent ocular hypertension (OHT) following intravitreal [Avastin] injections in patients with no personal or family history of glaucoma or ocular hypertension, Dr. Adelman said. "We found that sustained, high [eye pressure] may occur after only one anti-VEGF injection, but more typically after multiple injections. Patients' ocular hypertension may continue over several AMD treatments and may require [eye pressure] lowering therapy," he added.
View all news updates for macular degeneration
Disclaimer: The information provided in this section is a public service of the BrightFocus Foundation, and should not in any way substitute for the advice of a qualified healthcare professional, and is not intended to constitute medical advice. Although we take efforts to keep the medical information on our website updated, we cannot guarantee that the information on our website reflects the most up-to-date research. Please consult your physician for personalized medical advice; all medications and supplements should only be taken under medical supervision. BrightFocus Foundation does not endorse any medical product or therapy.
Some of the content in this section is adapted from other sources, which are clearly identified within each individual item of information.