Immune mechanism underlying AMD

Jinbo Liu, MD
Cleveland Clinic Foundation (Cleveland, OH)
Year Awarded:
2008
Grant Duration:
April 1, 2008 to March 31, 2012
Disease:
Macular Degeneration
Award Amount:
$100,000
Grant Reference ID:
M2008063
Award Type:
Standard
Award Region:
US Midwestern

Identification of autoreactive T cells in AMD Patients

Summary

The experiments in this proposal will address the mechanisms underlying immune attack in the retina. This information could lead to treatment approaches not currently available.

Details

The back of the eye where light is detected is a site where light induced modifications of occular components can occur as individuals age, and these modifications accumulate. The immune system is designed to distinguish anything that differs from normal body components, so these modifications can cause the immune system to attack the back of the eye and compromise vision. The experiments in this proposal will address the mechanisms underlying this immune attack. This information could lead to treatment approaches not currently available.