Advanced Glycation Endproduct Mediated Cholesterol Deposition in Bruch's Membrane

James Handa
Wilmer Eye Institute (Baltimore, MD)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to March 31, 2007
Disease:
Macular Degeneration
Award Amount:
$99,545
Grant Reference ID:
M2005041
Award Type:
Standard
Award Region:
US Northeastern

Advanced Glycation Endproduct Mediated Cholesterol Deposition in Bruch's Membrane

Details


When looking at AMD eyes under the microscope, the most distinguishing change is basal deposits, or accumulations of material within Bruch's membrane, a specialized scaffold upon which the retinal pigment epithelium (RPE) attaches. Prior to basal deposit formation, cholesterol (fat) is deposited into Bruch's membrane. Dr. Handa believes that understanding how cholesterol gets deposited into Bruch's membrane will help researchers to design targeted new treatments that prevent the onset of AMD or slow the inevitable progression from early to late disease.

Publications

Wu T, Tian J, Cutler RG, Telljohann RS, Bernlohr DA, Mattson MP, Handa JT. Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells. Lab Invest. 2010 Jun;90(6):906-14. Epub 2009 May 11. PubMed Icon Google Scholar Icon