Zebrafish May Hold Key To Repairing Serious Eye Conditions
BrightFocus-Supported Researchers Take An Important Step In Understanding Retina Regeneration
February 15, 2012
Source: Developmental Cell
Findings: Zebrafish, unlike humans, can regenerate their
retinas if they get injured. BrightFocus Foundation
supported Dr. Daniel Goldman and colleagues with a National Glaucoma Research
grant to study zebrafish for clues towards developing retinal regeneration
approaches in humans. The scientists found that when a zebrafish's retina is
damaged, a master regulator protein, called HB-EGF, sets in motion a series of
changes that cause Müller glia retina cells to become stem cells that then
repair the damage.
Significance: Müller glia cells are often left intact in
a retina damaged by disease, so these cells are great targets for future
therapy. The next step will be to determine if HB-EGF and associated
proteins can stimulate stem cell repair of a mouse's retina. If so, Dr.
Goldman's discovery may suggest new strategies for treating glaucoma.
University of Michigan Health System research into the mechanisms by which zebrafish are able to regenerate damaged retinas after injury, suggests new strategies for one day being able to do the same in humans—potentially allowing doctors to slow or reverse conditions like macular degeneration and glaucoma.
Building on previous studies, Daniel Goldman, Ph.D., a professor at U-M's Molecular and Behavioral Neuroscience Institute and in the Department of Biological Chemistry, along with postdoctoral fellows Jin Wan and Rajesh Ramachandran, discovered that heparin-binding epidermal-like growth factor (HB-EGF) plays a critical role during retina regeneration. Their findings were published in Developmental Cell.
“We found that this factor is sufficient to activate the whole process,” says Goldman.
When a zebrafish's retina is damaged, HB-EGF is released and sets in motion a series of changes that cause certain cells in the retina known as Muller glia to revert to a stem-cell state from which they can generate new cells and repair the damage. The researchers found that HB-EGF stimulated Muller glia to revert to a stem cell even in fish with uninjured eyes.
The next step, says Goldman, will be to explore if this factor and related pathways can stimulate Muller glia dedifferentiation and stem cell formation in mammals.
Adapted from the University of Michigan
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