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New Research Explores Link Between Increased Alzheimer’s Disease Risk And Inadequate Sleep

Researchers say disruption in normal sleep cycle may interfere with the body clearing away a marker for Alzheimer's disease from the brain

September 30, 2011

Researchers at Washington University School of Medicine in St. Louis have discovered that levels of a marker for Alzheimer's disease increase in the day but decrease during sleep and this finding could explain the increased risk of the cognitive disorder among older adults, who often sleep less and have fewer periods of deep slumber.
 
The marker, a byproduct of brain activity called amyloid beta, rises and falls in the spinal fluid in a daily pattern that echoes the sleep cycle. Researchers say the pattern is strongest in healthy young people. The brain's relative inactivity during sleep may provide an opportunity to finish clearing away amyloid beta from the brain through the spinal fluid and other mechanisms.
 
In the study, published online in Archives of Neurology, Yafei Huang, Ph.D., a postdoctoral research scholar, former research technician Rachel Potter and Randall Bateman, M.D., associate professor of neurology, report that the normal highs and lows of amyloid beta levels in the fluid that surrounds the brain and spinal cord begin to flatten in older adults, whose sleep periods are often shorter and more prone to disruption. In older adults with brain plaques linked to Alzheimer's disease, the ebb and flow is eradicated, and amyloid beta levels are close to constant, researchers found.
 
Link Between Sleep Deprivation and Alzheimer's
 
The researchers conducted the study in partnership with Washington University's Sleep Medicine Center.
 
“In healthy people, levels of amyloid beta drop to their lowest point about six hours after sleep, and return to their highest point six hours after maximum wakefulness,” Bateman says.  “We looked at many different behaviors, and the transitions between sleep and wakefulness were the only phenomena that strongly correlated with the rise and fall of amyloid beta in the spinal fluid.”
 
Older adults often sleep less and have fewer periods of deep slumber. A number of factors linked to aging, such as reduced exercise levels, can disrupt the normal daily patterns of sleep and waking. These disruptions often become more pronounced as individuals age. The risk of Alzheimer's disease also increases with age.
 
“We've known for some time that significant sleep deprivation has negative effects on cognitive function comparable to that of alcohol intoxication,” Stephen Duntley, MD, professor of neurology and director of the center says. “But it's recently become apparent that prolonged sleep disruption and deprivation can actually play an important role in pathological processes that underlie diseases. This connection to Alzheimer's disease isn't confirmed yet in humans, but it could be very important.”
 
Research Methodology
 
Scientists studied three sets of subjects: a group age 60 and older who tested positive for the presence of amyloid beta plaques in the brain; a group in the same age range who did not have plaques; and a group of healthy persons ages 18-60. Researchers used a spinal tap to monitor amyloid beta in the spinal fluid hourly for 24 to 36 hours and videotaped patients' activities and monitored their brain activity during that period.
 
In the group with brain plaques, amyloid beta levels were close to constant. But in the other two groups, the levels regularly rose and fell in a snakelike, sinusoidal pattern. The highs and lows of this pattern were much more pronounced in younger subjects.
 
Lead author Yafei Huang, Ph.D., a statistical data analyst, reviewed the subjects' activities during the monitoring period at 30-second intervals. She grouped them into categories such as eating or drinking, watching television, using the bathroom and using a computer or text messaging.
 
None of these activities could be closely correlated with changes in amyloid beta levels. But peaks in sleep and wakefulness, assessed both by videotape and by records of patients' brain activity levels, consistently occurred before the peaks and valleys of amyloid beta levels.
 
Further Study
 
Researchers are testing if deliberate interruption of sleep in young healthy subjects disrupts the normal daily decrease in spinal amyloid beta. Scientists may follow these studies with tests of whether sleeping pills and other interventions that improve sleep help maintain the rise and fall of amyloid beta in the spinal fluid.
 
“It's still speculation, but there are tantalizing hints that better sleep may be helpful in reducing Alzheimer's disease risk,” Duntley says. “We know from a number of studies that exercise enhances sleep, and research also has shown that exercise is associated with decreased risk of Alzheimer's. Sleep might be one link through which that effect occurs.”

Adapted from the Washington University School of Medicine

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