Text Size Normal Text Sizing Button Medium Text Sizing Button Large Text Sizing Button Text Contrast Normal Contrast Button Reverse Contrast ButtonSwitch to Spanish Language Press Room Contact Us Sitemap Sign In Register
Link to Homepage About BrightFocus
BrightFocus
Donate Now Get Involved  
Alzheimer's Disease Research Macular Degeneration Research National Glaucoma Research


Stay Informed: Medical and Research Updates
Connect With Us!
 

 

Designer Compounds Inhibit Prion Infection in Cultured Cells

Lessons learned for future ways to combat Alzheimer’s disease

July 24, 2012
Source: Biomaterials

Findings:

A team of researchers from the University of Alberta in Canada have successfully tested in cell cultures a new class of drug compounds designed to inhibit the spread of prions—toxic, misfolded proteins that can spread in the brain. Dr. David Westaway, a former BrightFocus grantee, is the senior author on this publication. The new compounds are “multivalent,” which means they can grab and neutralize more than one prion protein at once, and also are more purified than previously-tested drug compound mixtures. The drugs created by Westaway’s team are too bulky to be used for treating humans or animals, but they show promise and new hope for future methods to combat neurodegenerative diseases.

Significance:

In Alzheimer’s disease, the toxic proteins, like tau and beta-amyloid, can fold, clump, and spread in ways similar to prion proteins found in other diseases. Lessons learned from these new types of drugs designed to combat prion diseases could lend new ideas to the future design of drugs for other neurodegenerative diseases, including Alzheimer’s.

View all news updates for Alzheimer's disease


Disclaimer: The information provided in this section is a public service of the BrightFocus Foundation, and should not in any way substitute for the advice of a qualified healthcare professional, and is not intended to constitute medical advice. Although we take efforts to keep the medical information on our website updated, we cannot guarantee that the information on our website reflects the most up-to-date research. Please consult your physician for personalized medical advice; all medications and supplements should only be taken under medical supervision. BrightFocus Foundation does not endorse any medical product or therapy.

Some of the content in this section is adapted from other sources, which are clearly identified within each individual item of information.

Shop for a Cause YouTube Twitter Connect With Us Pinterest Google+