Another Step Toward an Alzheimer’s Vaccine
January 15, 2013
Source: Proceedings of the National Academy of Sciences (PNAS)
A team of researchers from Université Laval, CHU de Québec, and pharmaceutical firm GlaxoSmithKline (GSK) have discovered a way to stimulate the brain's natural defense mechanisms in people with Alzheimer's disease. The details that are presented today in an early online edition of the Proceedings of the National Academy of Sciences (PNAS), open the door to the development of a treatment for Alzheimer's disease and a vaccine to prevent the illness.
One of the main characteristics of Alzheimer's disease is the production in the brain of a toxic molecule known as amyloid beta. Microglial cells, the nervous system's defenders, are unable to eliminate this substance, which forms deposits called senile plaques.
The team led by Dr. Serge Rivest, professor at Université Laval's Faculty of Medicine and researcher at the CHU de Québec research center, identified a molecule that stimulates the activity of the brain's immune cells. The molecule, known as MPL (monophosphoryl lipid A), has been used extensively as a vaccine adjuvant by GSK for many years, and its safety is well established.
In mice with Alzheimer's symptoms, weekly injections of MPL over a twelve-week period eliminated up to 80% of senile plaques. In addition, tests measuring the mice's ability to learn new tasks showed significant improvement in cognitive function over the same period.
The researchers see two potential uses for MPL. It could be administered by intramuscular injection to people with Alzheimer's disease to slow the progression of the illness. It could also be incorporated into a vaccine designed to stimulate the production of antibodies against amyloid beta. "The vaccine could be given to people who already have the disease to stimulate their natural immunity," said Serge Rivest. "It could also be administered as a preventive measure to people with risk factors for Alzheimer's disease."
"When our team started working on Alzheimer's disease a decade ago, our goal was to develop better treatment for Alzheimer's patients," explained Professor Rivest. "With the discovery announced today, I think we're close to our objective."
It should be noted that the authors made the following statement in the conclusion of their publication (quote from the PNAS publication):
“Although the safety of the MPL treatment regimen used here has not been confirmed in humans, this compound has been administered to hundreds of thousands of humans as an adjuvant in different vaccines and is currently used as a component of a marketed human vaccine (Cervarix).”
Adapted from EurekAlert!
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