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BrightFocus-Funded Research Links Anemia to Increased Risk of Dementia

August 5, 2013
Source: Neurology

BrightFocus Foundation’s Alzheimer’s Disease Research program is funding Dr. Kristine Yaffe, who is a UCSF professor of psychiatry, neurology, and epidemiology based at the San Francisco Veterans Affair Medical Center.

Please note the researchers did not investigate what type of anemia is associated with the risk of dementia, and iron deficiency is only one type. Since there are serious health consequences from having too much iron in your body, including injury or death caused by damage to the brain and liver, please do not make any changes to your diet or potential supplemental regimen before consulting with your healthcare professional.

Dr. Kristine Yaffe

Dr. Kristine Yaffe
Source: UCSF

Anemia, or low levels of red blood cells, may increase the risk of dementia, according to a new UC San Francisco-led study.

“Anemia is common in the elderly and occurs in up to 23 percent of adults ages 65 and older,” said senior author Kristine Yaffe, MD, a UCSF professor of psychiatry, neurology and epidemiology based at the San Francisco Veterans Affair Medical Center. “The condition has also been linked in studies to an increased risk of early death.”

For the study, published in the July 31 online issue of Neurology, 2,552 older adults between the ages of 70 and 79 were tested for anemia and also underwent memory and thinking tests over 11 years. Of those, 393 had anemia at the start of the study. At the end of the study, 445—or about 18 percent of all participants—developed dementia.

The research found that people who had anemia at the start of the study had a nearly 41 percent higher risk of developing dementia than those who were not anemic. The link remained after considering other factors, such as age, race, sex and education. The association was still substantial and significant after adjusting for potential confounders, including comorbidities and other markers of red cell health.

Of the 393 people with anemia, 89 people, or 23 percent, developed dementia, compared to 366 of the 2,159 people who did not have anemia, or 17 percent.

The researchers did not investigate the type of anemia associated with the increased risk of dementia. Iron deficiency is one major type.

“There are several explanations for why anemia may be linked to dementia,” Yaffe said. “For example, anemia may be a marker for poor health in general, or low oxygen levels resulting from anemia may play a role in the connection. Reductions in oxygen to the brain have been shown to reduce memory and thinking abilities and may contribute to damage to neurons.”

Adapted from the University of California San Francisco

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Disclaimer: The information provided in this section is a public service of the BrightFocus Foundation, and should not in any way substitute for the advice of a qualified healthcare professional, and is not intended to constitute medical advice. Although we take efforts to keep the medical information on our website updated, we cannot guarantee that the information on our website reflects the most up-to-date research. Please consult your physician for personalized medical advice; all medications and supplements should only be taken under medical supervision. BrightFocus Foundation does not endorse any medical product or therapy.

Some of the content in this section is adapted from other sources, which are clearly identified within each individual item of information.

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